Document Actions

You are here: Home Faculty Professors Aktories

Aktories

Prof. Dr. Dr
Klaus Aktories

Institute of Experimental and Clinical Pharmacology
and Toxicology
Department I
Head of Department
Phone: 0049-761-203-5301

portal.uni-freiburg.de/pharmakologie

 

CV

  • 1978-1984 Research Associate Department of Pharmacology, University of Heidelberg
  • 1985-1989 Associate Professor (C2) Rudolf-Buchheim-Institute of Pharmacology, University of Gießen
  • 1989-1991 Associate Professor (C3), Institute of Pharmacology, University of Essen
  • 1991-1994 Full Professor (C4), Institute of Pharmacology and Toxicology, University of the Saarland
  • Since 1995 Full Professor (C4) and Head of Department  I, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg

Focus of research

  • Molecular pharmacology and toxicology of bacterial protein toxins
  • Toxins acting on the cytoskeleton and on  GTP-binding proteins
  • Application of bacterial toxins as anti-tumor drugs and as cell biological tools

Selected publications

  • Nölke T, Schwan C, Lehmann F, Østevold K, Pertz O, Aktories K. Septins guide microtubule protrusions induced by actindepolymerizing toxins like Clostridium diffi cile transferase (CDT). Proc Natl Acad Sci U S A. 2016; 113:7870-5.
  • Jank T, Eckerle S, Steinemann M, Trillhaase C, Schimpl M, Wiese S, van Aalten DM, Driever W, Aktories K. Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafi sh embryos. Nat Commun. 2015; 6:7807.
  • Jank T, Bogdanović X, Wirth C, Haaf E, Spoerner M, Böhmer KE, Steinemann M, Orth JH, Kalbitzer HR, Warscheid B, Hunte C, Aktories K. A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins. Nat Struct Mol Biol. 2013; 20:1273-80.
  • Papatheodorou P, Carette JE, Bell GW, Schwan C, Guttenberg G, Brummelkamp TR, Aktories K. Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium diffi cile transferase (CDT). Proc Natl Acad Sci U S A. 2011; 108:16422-7.
  • Lang AE, Schmidt G, Schlosser A, Hey TD, Larrinua IM, Sheets JJ, Mannherz HG, Aktories K. Photorhabdus luminescens toxins ADP-ribosylate actin and RhoA to force actin clustering. Science. 2010; 327:1139-42.