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Arnold

Prof. Dr.
Sebastian Arnold

Institute of Experimental and Clinical Pharmacology
and Toxicology
Department II
Phone: 0049-761/203-96819

http://www.arnold-lab.com/

 

CV

  • 1994-2001 Medical training, University of Freiburg
  • 1997-2000 MD thesis, Max-Planck-Institute of Immunobiology, Freiburg
  • 2001-2004 Clinical Resident, Medical Center - University of Freiburg, Department of Medicine IV, Freiburg
  • 2004-2008 Postdoctoral Fellow, Cell and Developmental Biology, University of Oxford, UK
  • 2010-2016 Emmy Noether Group Leader, Medical Center - University of Freiburg, Department of Medicine IV, Freiburg
  • Since 2017 W3-Professor of Regenerative Pharmacology (Heisenberg), University of Freiburg

Focus of research

  • Developmental and Stem Cell Biology, Regeneration
  • Cellular Specification and Differentiation
  • Molecular Genetics

Selected Publications

  • Kaminski MM, Tosic J, Kresbach C, Engel H, Klockenbusch J, Muller AL, Pichler R, Grahammer F, Kretz O, Huber TB, Walz G, Arnold SJ*, and Lienkamp SS*. Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors. Nature cell biology. 2016; 18: 1269-1280. *corresponding authors
  • Funk MC, Bera AN, Menchen T, Kuales G, Thriene K, Lienkamp SS, Dengjel J, Omran H, Frank M, and Arnold SJ. Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells. The EMBO journal. 2015; 34, 1078-1089.
  • Zhu D, Holz S, Metzger E, Pavlovic M, Jandausch A, Jilg C, Galgoczy P, Herz C, Moser M, Metzger D, Gunther T, Arnold SJ*, and Schule R*. Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells. Nature communications. 2014; 5: 3174. *corresponding authors
  • Costello I, Pimeisl IM, Drager S, Bikoff EK, Robertson EJ, and Arnold SJ. The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation. Nature cell biology. 2011; 13, 1084-1091.
  • Arnold SJ, Huang GJ, Cheung AFP, Era T, Nishikawa S, Bikoff EK, Molnar Z, Robertson EJ, and Groszer M. The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. Genes Dev. 2008; 22, 2479-84.

Research methods

  • Genome Engineering/Advanced Mouse Genetics
  • Embryonic Stem cell Differentiation, Early Embryogenesis
  • Life cell/embryo imaging (Light Sheet Microscopy)