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Bruckner-Tuderman

Prof. Dr. Dr. h.c.
Leena Bruckner-Tuderman

Department of Dermatology
Medical Director
Phone: 0049-761-27067160

www.uniklinik-freiburg.de/hautklinik

CV

  • 1971-1976 Medical School and academic dissertation, University of Oulu, Finland
  • 1977-1983 Postdoctoral research training, Rutgers Medical School, N.J. USA and Biocenter, University of Basel, Switzerland
  • 1984-1987 Recidency and habilitation in Dermatology, University Hospital Zurich, Switzerland
  • 1988-2002 Attending physician, SNF-SCORE Stipendiate, DFG-Heisenberg-Stipendiate, Apl-Professor, University Hospital Zurich and University Hospital Münster
  • Since 2003 Full professor (C4) and Medical Director, Department of Dermatology, Medical Center – University of Freiburg

Focus of research

  • Molecular biology and pathology of the extracellular matrix and basement membranes
  • Skin fragility: causes, disease mechanisms and novel biological therapies
  • Rare Diseases

Selected publications

  • Mittapalli VR, Madl J, Löffek S, Kiritsi D, Kern JS, Römer W, Nyström A, Bruckner-Tuderman L. Injury-driven stiffening of the dermis expedites skin carcinoma progression. Cancer Research. 2016; 76, 940-51.
  • Nystrom A, Thriene K, Mittapalli V, Kern JS, Kiritsi D, Dengjel J, Bruckner-Tuderman L. Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms.EMBO Mol Med. 2015; 7:1211-28.
  • Nyström A, Velati D, Mittapalli VR, Kern JS, Fritsch A, Bruckner-Tuderman L. Collagen VII plays a dual role in wound healing. J Clin Invest. 2013; 123, 3498-3509.
  • Küttner V, Mack C, Rigbolt KTG, Kern JS, Schilling O, Busch H, Bruckner-Tuderman L, Dengjel J. Global remodeling of cellular microenvironment due to loss of collagen VII. Mol Syst Biol, Online Publication 16.04.2013, DOI: MSB.2013.17.
  • Has C*, Spartà G*, Kiritsi D*, Weibel L, Moeller A, Vega-Warner V, Waters A, He Y, Anikster Y, Esser P, Straub BK, Hausser I, Bockenhauer D, Dekel B, Hildebrandt F, Bruckner-Tuderman L§, Laube GF§. Integrin a3 mutations with kidney, lung and skin disease New Engl J Med. 2012; 366, 1508-1514 (*, §, equal contribution).

Research methods

  • Molecular genetics
  • Culture of primary cells
  • Organotypic cultures
  • Mouse models for diseases