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Henneke

Prof. Dr.
Philipp Henneke

Institute for Infection Prevention and Control
Medical Director
Phone: 0049-761-270-82051

www.uniklinik-freiburg.de/iuk

CV

  • 1987-1994 Studies of Medicine, FU Berlin, and Imperial College, London
  • 1994-2001 Fellow in Pediatrics at FU Berlin (Pediatrics), from 1999 at Univ. of Massachusetts Medical Center (Immunology)
  • 2001 Assistant Professor, University of Massachusetts Medical Center and Lecturer, Harvard Medical School
  • 2003 Assistant Professor in Pediatric Infectious Diseases, Medical Center - University of Freiburg
  • Since 2012 Full Professor of Infection and Immunity (W3), Head of Division of Pediatric Infectious Diseases and Rheumatology, Medical Center - University of Freiburg
  • Since 2023 Full Professor of Infection Immunity and Control (W3) and Director, Institute for Infection Prevention and Control, Medical Center - University of Freiburg
  • Since 2023 Coordinator TRR SFB 359 „Perinatal Development of Immune Cell Topology -PILOT"

Focus of research

  • Immunological control of streptococci and staphylococci as harmless colonizers at mucocutaneous sites. Impact of individual development on this control. This work involves animal models as well as cells from patients with immunodeficiency disorders.
  • Molecular interaction and signaling events between macrophages, monocytes and granulocytes with bacteria and herpes viruses. Areas of interest are receptor-effector interactions, cellular programming and handling of pathogens. Reporter assays, confocal microscopy and live cell imaging are critical tools.
  • Development and differentiation of macrophage subsets in vivo.

Selected publications

  • Baasch, S., P. Giansanti, J. Kolter,…Z. Ruzsics, and P. Henneke. Cytomegalovirus subverts macrophage identity. Cell 2021; 184:1-20.
  • Lösslein, A., F. Lohrmann, …and P. Henneke. 2021. Monocyte progenitors are antimycobacterial effector cells. Nat Comm 2021; 12:2027.
  • Kolter, J., R. Feuerstein, … T. Lammermann, M. Prinz, and P. Henneke. A subset of skin macrophages contributes to surveillance and regeneration of local nerves. Immunity. 2019; 50:1482-1497.
  • Herrtwich L, … Henneke P, Triantafyllopoulou A. DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas. Cell. 2016; 167(5):1264-1280.
  • Pannicke U*, Baumann B*, Fuchs S*, Henneke P*, … Schwarz K. Deficiency of innate and acquired immunity caused by an IKBKB mutation. N Engl J Med 2013; 369:2504-14.* Equal contribution.