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Hunte

Prof. Dr.
Carola Hunte

Institute of Biochemistry and Molecular Biology
Department of Biochemistry I
Phone: 0049-761-203-5279

http://www.biochemie.uni-freiburg.de/praambel-en?set_language=en

CV

  • 1982-1989 Studies of Biology (Diploma), Bielefeld, Exeter (UK), Bonn
  • 1989-1993 PhD (Dr. rer. nat.), University of Bonn
  • 1995-2007 Postdoctoral fellow (Mentor Prof. Dr. H. Michel), group leader, Max Planck Institute of Biophysics, Frankfurt/M.
  • 2007-2010 Chair in Membrane Biology, University of Leeds (UK)
  • Since 2010 Full Professor of Biochemistry and Structural Biology (W3), University of Freiburg
  • Since 2014 Dean of Research of the Faculty of Medicine

Focus of research

  • Aim of the structural biology research is the elucidation of structure, mechanism and function of medically relevant membrane proteins and signalling protein complexes.
  • Special focus is on membrane multi-protein complexes of cellular respiration  and  on ion transport proteins and their signalling complexes.
  • The core area for structure determination is the 3-dimensional crystallization and X-ray crystallography

Selected publications

  • Zickermann V*, Wirth C, Nasiri H, Siegmund K, Schwalbe H, Hunte C*, Brandt U*. Mechanistic Insight from the Crystal Structure of Mitochondrial Complex. Science. 2015; 347, 44-49,*corresponding author.
  • Birth D, Kao WC, Hunte C. Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action. Nat. Comm. 2014; 5, 4029.
  • Hunte C*, Screpanti E, Venturi M, Rimon A, Padan E*, Michel H* . Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH. Nature. 2005; 435, 1197-1202 *corresponding author.
  • Lange C, Hunte C. Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c. Proc. Natl. Acad. Sci. USA. 2002; 99, 2800-2805.
  • Lange C, Nett JH, Trumpower BL, Hunte C. Specific roles of tightly bound phospholipids in the yeast cytochrome bc1 complex structure. EMBO J. 2001; 20, 6591-6600.

Research methods

  • Semi-automated high-throughput crystallization and crystal imaging robotics.
  • Crystallization of membrane proteins with recombinant antibodies.
  • Biophysical methods for characterization of membrane proteins, enzymes, protein complexes.