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Pahl

Prof. Dr.
Heike Pahl

Department of Medicine I
Phone: 0049-761-27063400

www.uniklinik-freiburg.de/medizin1/forschung

CV

  • 1987 B.A. Wellesley College
  • 1990 M.A. Harvard Medical School
  • 1992 Ph.D. Harvard Medical School
  • 1997 Habilitation, Medical School, University of Freiburg
  • Since 2012 Full Professor (C3) of Molecular Hematology, Medical Center - University of Freiburg

Focus of research

  • Molecular etiology of myeloid neoplasms
  • Molecular and cellular biology of myeloid and erythroid differentiation
  • Myeloid and erythroid transcription factors

Selected publications

  • Jutzi JS, Bogeska R, Nikoloski G, Schmid CA, Seeger TS, Stegelmann F, Schwemmers S, Gründer A, Peeken J, Gothwal M, Wehrle J, Aumann K, Hamdi K, Dierks, C, Wang W, Döhner K, Jansen JH, Pahl HL. MPN patients harbor recurrent truncating mutations in transcription factor NF-E2, J. Ex. Med. 2013; 210:1003-1019.
  • Kaufmann KB, Gründer A, Hadlich T, Wehrle J, Gothwal M, Bogeska R, Seeger TS, Kayser S, Pham KB, Jutzi JS, Ganzenmüller L, Steinemann D, Schlegelberger B, Wagner JM, Jung M, Will B, Steidl U, Aumann K, Werner M, Günther T, Schüle R, Rambaldi A, Pahl HL. A novel murine model of myeloproliferative disorders generated by overexpressionof the transcription factor NF-E2. J. Exp. Med. 2012; 209:35-50.
  • Wang W, Schwemmers S, Hexner EO, Pahl HL. AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2. Blood. 2010; 116:254-266.
  • Klippel S, Strunck E, Temerinac S, Meinhardt G, Mohr U, Leichtle R, Griesshammer M, Heimpel H, Pahl HL. Quantifi cation of PRV-1 mRNA distinguishes Polycythemia vera from Secondary Erythrocytosis. Blood. 2003; 102: 3569-3574.
  • Klippel S, Strunck E , Busse CE, Behringer D, Pahl HL. Biochemical Characterization of PRV-1, a Novel Hematopoietic Cell Surface Receptor, which is Overexpressed in Polycythemia rubra vera. Blood. 2002; 100: 2441-2448.