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Rolauffs

Prof. Dr.
Bernd Rolauffs

Department of Orthopedics and Trauma Surgery
Phone: 0049-761-270-26101

www.uniklinik-freiburg.de/unfallchirurgie

CV

  • 2000-2002 Postdoctoral Research Fellowship, Rush University Medical Center, Department of Biochemistry, Prof. Klaus Kuettner's laboratory, Chicago, Illinois, United States
  • 2003-2005 Postdoctoral Research Fellowship, Massachusetts Institute of Technology (MIT), Center for Biomedical Engineering, Prof. Alan Grodzinsky's laboratory, Cambridge, Massachusetts, United States
  • 2008-2016 Laboratory Head, University of Tuebingen, BG Trauma Center, Laboratory for Molecular Biomechanics, Tuebingen, Germany
  • 2012-2016 Assistant Director, University of Tuebingen, Siegfried-Weller-Institute for Trauma Research, BG Trauma Center, Tuebingen, Germany
  • Since 2016 Full Professor of Tissue Replacement (W3), Department of Orthopedics and Traumatology, Laboratory for Cell & Tissue Engineering, Medical Center – University of Freiburg

Focus of research

  • Engineering of defined cell geometries via biophysical stimuli, relevant for the biomaterial- and biomechanical-assisted control of primary and progenitor cells
  • Visualization, quantification, interpretation and mechanisms of the spatial organization of cells within the native tissue, relevant for the early diagnosis of degenerative and traumatic changes and for biological surrogate tissues
  • Mechano-biology of cells, tissues, and bio-artificial surrogate tissues, relevant for understanding biomechanical (over-)loads as biophysical stimuli /trauma mechanisms, and for developing regenerative therapies

Selected publications

  • Uynuk-Ool T et al. The geometrical shape of mesenchymal stromal cells measured by quantitative shape descriptors is determined by the stiffness of the biomaterial and by cyclic tensile forces. J Tissue Eng Regen Med. 2017; doi: 10.1002/term.2263.
  • Rothdiener M et al. Stretching human mesenchymal stromal cells on stiffnesscustomized collagen type I generates a smooth muscle marker profi le without growth factor addition. Sci Rep. 2016; 6:35840.
  • Felka T et al. Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology. Osteoarthritis Cartilage. 2016; 24:1200-1209.
  • Aicher WK, Rolauffs B. The spatial organization of joint surface chondrocytes: review of its potential roles in tissue functioning, disease, and early pre-clinical diagnosis of osteoarthritis. Ann Rheum Dis. 2014; 73(4):645-53.