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Timmers

Prof. Dr.
Marc Timmers

Department of Urology
German Cancer Consortium
Center for Clinical Research
Phone: 0049-761-270-63980

dktk.dkfz.de/en/sites/freiburg

CV

  • 1990-1992 post-doctoral fellow lab Prof. Phillip Sharp (Nobel laureate Medicine 1993), MIT, Cambridge, USA
  • 1992-1996 Assistant professor, Medical faculty, Utrecht University, The Netherlands
  • 1996-2000 Associate professor, Medical faculty, Utrecht University, The Netherlands
  • 2001-2017 Full Professor of Epigenetics and Gene Regulation Utrecht University, the Netherlands
  • Since 2017 Full Professor of Medical Epigenetics (W3), German Cancer Consortium, Center for Clinical Research, Medical Center - University of Freiburg

Focus of research

  • Epigenetics
  • Gene Regulation
  • Cancer

Selected publications

  • Koster MJ, Snel B, Timmers HT. Genesis of chromatin and TBP dynamics in the origin of species. Cell. 2015; 161:724-36.
  • Dreijerink KM et al. Breast cancer predisposition in Multiple Endocrine Neoplasia type 1. NEJM. 2014; 371:583-4.
  • Pijnappel WW, Esch D, Baltissen MP, Wu G, Mischerikow N, Bergsma AJ, van der Wal E, Han DW, Bruch Hv, Moritz S, Lijnzaad P, Altelaar AF, Sameith K, Zaehres H, Heck AJ, Holstege FC, Schöler HR, Timmers HT. A central role for TFIID in the pluripotent transcription circuitry. Nature. 2013; 495:516-519.
  • van Werven FJ, van Bakel H, van Teeffelen HA, Altelaar AF, Koerkamp MG, Heck AJ, Holstege FC, Timmers HT.Cooperative action of NC2 and Mot1p to regulate TATA-binding protein function across the genome. Genes Dev. 2008; 22:2359-2369.
  • Vermeulen M, Mulder KW, Denissov S, Pijnappel WW, van Schaik FM, Varier RA, Baltissen MP, Stunnenberg HG, Mann M, Timmers HT.Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine four. Cell. 2007; 131:58-69.

Research methods

  • Bioreactors for large suspension cultures
  • Protein chromatography systems
  • Mass spectrometry