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Prof. Dr. Dr.
Melanie Börries

Institute of Medical Bioinformatics and Systems Medicine


  • 2001-2005 MD/PhD fellowship Dr. phil., Cell Biology, University of Basel, Schweiz and Dr. med., Human-Medicine, Medical University Lübeck
  • 2005-2009 Postdoctoral fellow at the Institute of Experimental and Clinical Pharmacology and Toxicology, University Freiburg
  • 2009-2012 Project Leader at the Freiburg Institute for Advanced Studies/School of LifeNet
  • Since 2013 Group Leader German Cancer Consortium (DKTK)
  • Since 2019 W3 Professor of Medical Bioinformatics and Director of the Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg

Focus of research

  • Big Data/Muli-Omics data analysis and data integration in medicine and research; Identification of disease biomarkers and prediction for therapy options using machine learning methods
  • Pipeline development for high-throughput data in clinical research and clinical application
  • Analysis of sequencing data for Molecular Tumor Boards and consortium MIRACUM
  • Strategies for innovative health care to benefit patients

Selected publications

  • Chakraborty S, Andrieux G, Hasan AMM, Ahmed M, Hosen MI, Rahman T, Hossain MA, Boerries M. Harnessing the tissue and plasma lncRNA-peptidome to discover peptide-based cancer biomarkers. Sci Rep. 2019 Aug 23;9(1):12322
  • Mastroianni J, Stickel N, Andrlová H, Hanke K, Melchinger W, Duquesne S, Schmidt D, Falk M, Andrieux G, Pfeifer D, Dierbach H, Schmitt-Graeff A, Meiss F, Boerries M, Zeiser R. miR-146a controls immune response in the melanoma microenvironment. Cancer Res. 2019 Jan 1;79(1):183-195
  • Hoefflin, R.,Geißler, A.-L., Fritsch, R., Claus, R.,,Wehrle, J., Metzger, P., Reiser, M., Mehmed, L., Fauth, L., Heiland, D.H., Erbes, T., Stock, F.,,Csanadi, A., Miething, C., Weddeling, B., Meiss, F., von Bubnoff, D., Dierks, C., Ge, I., Brass, V., Heeg, S., Schäfer, H., Boeker, M., Rawluk, J., Botzenhart, E.M., Kayser, G., Hettmer, S., Busch, H., Peters, C., Werner, M., Duyster, J., Brummer, T., Boerries, M., Lassmann, S. and von Bubnoff, N. (2018). Personalized clinical decision making through implementation of a Molecular Tumorboard – a German single centre experience. JCO Precision Oncology
  • Klett H, Fuellgraf H, Levit-Zerdoun E, Hussung S, Kowar S, Küsters S, Bronsert P, Werner M, Wittel U, Fritsch R, Busch H, Boerries M. Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma. Front Genet. 2018 Apr 5;9:108
  • Mathew NR, Baumgartner F, Braun L,  Halbach S, Brummer T, Andrieux G, Börries M, Blazar BR, Zeiser R. Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nat Med. 2018 Mar;24(3):282-291

Research methods

  • Development and application of standardised workflows for analyses of omics data
  • High-Performance-Computer-Cluster (HPC)
  • Single Cell Analysis (10X Genomics)