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Prof. Dr.
Sven Diederichs

Department of Thoracic Surgery
Phone: 0049-761-270-77556


  • 2002-2004 Graduate Student, University Hospital Münster & University of Witten / Herdecke
  • 2005-2008 Postdoctoral Fellow, Harvard Medical School / Massachusetts General Hospital Cancer Center, Boston, USA
  • 2008-2014 Independent Junior Group Leader for "Molecular RNA Biology & Cancer", German Cancer Research Center (DKFZ), Heidelberg
  • Since 2015 Head of Division "RNA Biology & Cancer", German Cancer Research Center (DKFZ), Heidelberg
  • Since 2016 Full Professor (W3) and Head of Division "Cancer Research", Department of Thoracic Surgery, Medical Center – University of Freiburg

Focus of research

  • Regulation, functions & mechanisms of non-protein-coding RNAs in cancer
  • Genetic & epigenetic mechanisms in lung carcinogenesis
  • Cell migration and metastasis of lung cancer

Selected publications

  • S Dhamija*, CM Yang*, J Seiler, K Myacheva, M Caudron-Herger, A Wieland, M Abdelkarim, Y Sharma, M Riester, M Groß, J Maurer, S Diederichs: "A Pan-Cancer Analysis reveals Nonstop Extension Mutations causing SMAD4 Tumor Suppressor Degradation"
    Nature Cell Biology (2020) epub
  • M Gandhi, M Groß, JM Holler, SA Coggins, N Patil, JH Leupold, M Munschauer, M Schenone, CR Hartigan, H Allgayer, B Kim, S Diederichs: "The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer"
    Nature Communications (2020) 11: 3214
  • M Caudron-Herger, E Wassmer, I Nasa, AS Schultz, J Seiler, AN Kettenbach, S Diederichs: "Identification, quantification and bioinformatic analysis of RNA-dependent proteins by RNase treatment and density gradient ultracentrifugation using R-DeeP"
    Nature Protocols (2020) 15: 1338-1370
  • Y Sharma*, M Miladi*, S Dukare*, K Boulay*, M Caudron-Herger, M Groß, R Backofen, S Diederichs: "A pan-cancer analysis of synonymous mutations"
    Nature Communications (2019) 10: 2569
  • M Caudron-Herger, SF Rusin, ME Adamo, J Seiler, V Schmid, E Barreau, AN Kettenbach, S Diederichs: "R-DeeP: Proteome-wide and Quantitative Identification of RNA-dependent Proteins by Density Gradient Ultracentrifugation"
    Molecular Cell (2019) 75: 184-199

Research methods

  • Molecular & Cellular Biology of RNA
  • CRISPR/Cas Libraries & Screens
  • Bioinformatics