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Prof. Dr.
Olaf Groß

Institute of Neuropathology
Phone: 0049-761-270-50780 neuropathology


  • 1997-2003 Studies of biology, Technische Universität München, Dipl. Biol.
  • 2003-2008 Dissertation research in the laboratory of Dr. Jürgen Ruland Technische Universität München, Dr. rer. nat.
  • 2008-2012 Postdoctoral research fellow in the laboratory of Prof. Jürg Tschopp, Département de Biochimie, Université de Lausanne
  • 2012-2017 Independent research group leader, Klinikum rechts der Isar, Technische Universität München
  • Since 2017 Full Professor of Experimental Neuropathology (W3), Medical Center - University of Freiburg

Focus of research

  • Signalling and metabolism
  • Innate immunity and danger-recognition
  • Molecular and cellular basis of inflammation

Selected publications

  • Groß CJ*, Mishra R*, Schneider KS, Médard G, ... Kuster B, Ruland J, Schneider S, Perocchi F, Groß O. K+ Effl ux-Independent NLRP3 Infl ammasome Activation by Small Molecules Targeting Mitochondria. Immunity. 2016; 45(4):761-773.
  • Groß O*, Yazdi AS*, Thomas CJ, ... Tschopp J. Infl ammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity. 2012; 36(3):388-400.
  • Poeck H*, Bscheider M*, Groß O*, ... Hartmann G, Hornung V, Ruland J. Recognition of RNA virus by RIG-I results in activation of CARD9 and infl ammasome signaling for interleukin-1 beta production. Nat Immunol. 2010; 11(1):63-69.
  • Groß O*, Poeck H*, Bscheider M, ...Tschopp J, Ruland J. Syk kinase signalling couples to the Nlrp3 infl ammasome for anti-fungal host defence. Nature. 2009; 459(7245):433-436.
  • Groß O, Gewies A, Finger K, ... Ruland J. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature. 2006; 442(7103):651-656.

Research methods

  • Models of infectious, inflammatory, and metabolic diseases
  • Targeted and untargeted metabolomics, metabolic flux analysis
  • Confocal and superresolution microscopy