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Prof. Dr.
Robert Grosse

Institute of Experimental and Clinical Pharmacology and Toxicology
Department I
Head of Department
Phone: 0049-761-203-5313


  • 1994-1999 Medical School and doctoral thesis work, Institute of Pharmacology, Freie Universität Berlin
  • 2000-2003 Postdoctoral fellow, London Research Institute, Cancer Research UK, London, UK
  • 2004-2009 Emmy Noether Group leader, University of Heidelberg,
  • 2009-2018 Full professor and chair, Institute of Pharmacology, University of Marburg
  • Since 2019 Full professor and chair, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg

Focus of research

  • Signalregulation of the cytoskeleton in migration and mitosis
  • Actin assembly in cancer cell invasion
  • Regulation and function of nuclear actin dynamics and nuclear organization

Selected publications

  • Wang Y, Sherrard A, Zhao B, Melak M, Trautwein J, Kleinschnitz E-M, Tsopoulidis N, Fackler O, Schwan C, Grosse R. GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics. Nat Commun 10, 5271 (2019)
  • Baarlink C, Plessner M, Sherrard A, Morita K, Misu S, Virant D, Kleinschnitz EM, Harniman R, Alibhai D, Baumeister S, Miyamoto K, Endesfelder U, Kaidi A, Grosse R.; A transient pool of nuclear F-actin at mitotic exit controls chromatin organization, Nat Cell Biol. 2017 Dec;19(12):1389-1399.
  • Wang Y, Arjonen A, Pouwels J, Ta H, Pausch P, Bange G, Engel U, Pan X, Fackler OT, Ivaska J, Grosse R.; Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα; Dev Cell. 2015 Aug 24;34(4):475-83.
  • Baarlink C, Wang H, Grosse R.; Nuclear actin network assembly by formins regulates the SRF coactivator MAL Science. 2013 May 17;340(6134):864-7.
  • Brandt DT, Baarlink C, Kitzing TM, Kremmer E, Ivaska J, Nollau P, Grosse R.; SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin. Nat Cell Biol. 2009 May;11(5):557-68.

Research methods

  • High resolution live cell imaging
  • Optogenetics of the cytoskeleton
  • Real time spinning disc and confocal microscopy