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Prof. Dr.
Lutz Hein

Institute of Experimental and Clinical Pharmacology and Toxicology
Department II
Head of Department
Phone: 0049-761-203-5313


  • 1982-1988 Medical school, MD-thesis, University of Kiel, Germany
  • 1988-1991 Residency in pharmacology, University of Kiel, Germany
  • 1991-1996 Postdoctoral fellow and Clinical Assistant Professor, Stanford University, USA
  • 1996-2004 Habilitation and Professor of Pharmacology, University of Würzburg, Germany
  • Since 2004 Full Professor (C4/ W3) of Pharmacology and Toxicology, University of Freiburg

Focus of research

  • Molecular mechanisms of heart failure
  • Cardiovascular pharmacology
  • Epigenetics

Selected publications

  • Mayer SC, Gilsbach R, ... Hein L. Adrenergic repression of the epigenetic reader MeCP2 facilitates cardiac adaptation in chronic heart failure. Circ Res. 2015; 117, 622-633.
  • Gilsbach R, Preissl S, Grüning BA, Schnick T, Burger L, Benes V, Würch A, Bönisch U, Günther S, Backofen R, Fleischmann BK, Schübeler D, Hein L. Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease. Nature Communications. 2014; 5:5288.
  • Beetz N, ... Lohse MJ, Broeckel U, Hein L. Phosducin infl uences sympathetic activity and prevents stress-induced hypertension in humans and mice. J Clin Invest. 2009; 119, 3597-3612.
  • Philipp M, Brede M, Hadamek K, Gessler M, Lohse MJ, Hein L. Placental alpha2-adrenoceptors control vascular development at the interface between mother and embryo. Nature Genetics. 2002; 31, 311-315.
  • Hein L, Altman JD, Kobilka BK. Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission. Nature. 1999; 402, 181-184.

Research methods

  • Cardiovascular phenotyping of transgenic models
  • Fluorescence-based cell sorting
  • Epigenome analysis, next generation sequencing