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Prof. Dr.
Hartmut Hengel

Institute of Virology
Medical Director
Phone: 0049-761-203-6534


  • 1989 MD, University of Ulm (Prof. Dr. Hermann Wagner, PhD, Institute of Microbiology, Department of Immunology)
  • 1998 Habilitation in Virology, Venia legendi; Ludwig-Maximilians-Universität Munich
  • 2002 Appointment as Director and Professor at Robert Koch-Institute, Berlin
  • 2004-2012 Full professor and founding Director, Institute for Virology, Heinrich-Heine-University Düsseldorf
  • Since 2012 Full professor (W3) and Director of the Institute of Virology, Medical Center – University of Freiburg

 Focus of research

  • Experimental virology and immunobiology of cytomegaloviruses (CMV)
  • Viral immune evasion strategies
  • Clinical virology and vaccines

Selected publications

  • Corrales-Aguilar E, Trilling M, Hunold K, FiedlerM, Le VT, Reinhard H, Ehrhardt K, Mercé-Maldonado E, Aliyev E, Zimmermann A, Johnson DC, Hengel H. Human cytomegalovirus Fcγ binding proteins gp34 and gp68 antagonize Fcγ receptors I, II and III. PLoS Pathog. 2014; 10(5):e1004131.
  • Stern-Ginossar N, Weisburd B, Michalski A, Le VT, Hein MY, Huang SX, Ma M, Shen B, QianSB, Hengel H, Mann M, Ingolia NT, Weissman JS. Decoding human cytomegalovirus. Science. 2012; 338(6110):1088-93.
  • Trilling M, Le VT, Fiedler M, Zimmermann A, Bleifuss E, Hengel H. Identifi cation of DNAdamage DNA-binding protein 1 as a conditional essential factor for cytomegalovirus replication in interferon-γ-stimulated cells. PLoS Pathog. 2011; 7(6):e1002069.
  • Zimmermann A, Trilling M, Wagner M, Wilborn M, Bubic I, Jonjic S, Koszinowski U, Hengel H. A cytomegaloviral protein reveals a dual role for STAT2 in IFN-{gamma} signaling and antiviral responses. J Exp Med. 2005; 201(10):1543-53.
  • Hengel H, Koopmann JO, Flohr T, Muranyi W, Goulmy E, Hämmerling GJ, Koszinowski UH, Momburg F. A viral ER-resident glycoprotein inactivates the MHC-encoded peptide transporter. Immunity. 1997; 6(5):623-32.

Research methods

  • Mouse CMV infection model
  • BACmid-based mutagenesis