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Prof. Dr.
Sabine Rospert

Institute of Biochemistry and Molecular Biology
Department Biochemistry II
Head of Department
Phone: 0049-761-208-5259


  • 1981 Dr. rer. nat. Microbiology, University of Marburg, Institute of Prof. R.K. Thauer
  • 1998 Habilitation in Biochemistry, University of Basel, Switzerland, Institute of Prof. Dr. G. Schatz
  • 1997-1998 Independent research associate at the Biocenter, University of Basel, Switzerland
  • 1999-2003 Head of an independent junior research group at the MPI 'Enzymology of protein folding', Halle/Saale
  • Since 2003 Full Professor (W3), since 2005 Head of the Department Biochemistry II, University of Freiburg

Focus of research

  • Function of ribosome-bound chaperones in quality control of protein synthesis
  • Regulation of metabolic signalling pathways by chaperones
  • Mechanisms of protein targeting to the ER

Selected publications

  • Gumiero A, Conz C, Gesé GV, Z Zhang Y, Weyer FA, Lapouge K, Kappes J, von Plehwe U, Schermann G, Fitzke E, Wölfl e T, Fischer T, Rospert S. Sinning I Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain. Nature Communications. 2016; 24;7:13563.
  • Hübscher V, Mudholkar K, Chiabudini M, Fitzke E, Wölfl e T, Pfeifer D, Drepper F, Warscheid B, Rospert S. The Hsp70 homolog Ssb and the 14-3-3 protein Bmh1 jointly regulate transcription of glucose repressed genes in Saccharomyces cerevisiae. Nucleic Acids Res. 2016; 44(12):5629-45.
  • Karamyshev AL, Patrick AE, Karamysheva ZN, Griesemer DS, Hudson H, Tjon-Kon-Sang S, Nilsson I, Otto H, Liu Q, Rospert S, Heijne G, Johnson AE, Thomas PJ. Ineffi cient SRP Interaction with a Nascent Chain Triggers a mRNA Quality Control Pathway. Cell. 2014; 156:146-157.
  • Richly H, Rocha-Viegas L, Ribeiro JD, Demajo S, Gundem G, Lopez-Bigas N, Nakagawa T, Rospert S, Ito T, Di Croce L. Transcriptional activation of Polycomb-repressed genes by ZRF1. Nature. 2010; 468:1124-1128.
  • von Plehwe U, Berndt U, Conz C, Chiabudini M, Fitzke E, Sickmann A, Petersen A, Pfeifer D, Rospert S. The Hsp70 homolog Ssb is essential for glucose sensing via the SNF1 kinase network. Genes Dev. 2009; 23:2102-2115.