Schreiner

Institute of Virology
Phone: 0049-761-203-6625
sabrina.schreiner-gruber@uniklinik-freiburg.de
www.uniklinik-freiburg.de/virologie

2006-2010 PhD, University of Hamburg
2010-2014 Postdoc, Leibniz Institut für Experimentelle Virologie (LIV)
2014-2024 Group Leader, Institute of Virology, Technical University Munich, Institute of Virology, Helmholtz Center Munich
Since 2020 W2 professorship Virus replication in host chromatin within the DFG Excellence Cluster RESIST
Since 2023 W3 Professorship for Virology with focus on Molecular Virology, Institute of Virology, Freiburg University Medical Center

Infections in the immunocompromised host (HAdV, HBV)
Host-cell nuclear structures/ PML nuclear bodies and Virus-mediated modulation of posttranslational modifications (SUMO, Ubiquitin)
Generation & validation of novel anti-Adenovirus inhibitor options

Göttig L, Jummer S. Staehler L, Groitl P, Karimi M, Blanchette P, Kosulin K, Branton PE, Schreiner S., 2024. The Human Adenovirus PI3K-Akt activator E4orf1 is targeted by the tumor suppressor p53. J Virol. (manuscript accepted)
Hofmann S, Plank V, Groitl P, Skvorc N, Hofmann K, Luther J, Ko C, Zimmermann P, Bruss V, Stadler D, Carpentier A, Rezk S, Nassal M, Protzer U, Schreiner S., 2023. SUMO modification of HBV core mediates nuclear entry, PML association and efficient cccDNA formation. Microbiology Spectrum. e0044623.doi:10.1128/spectrum.00446-23.
Weiß C, Göttig L, Stubbe M, Hofmann S, Stadler D, Carpentier A, Protzer U, Schreiner S., 2023. Apobec3A deamination 1 capacity antagonizes efficient human adenovirus replication and gene expression. mBio. e0347822.doi:10.1128/mbio.03478-22.
Mai J, Stubbe M, Hofmann S, Masser S, Dobner T, Boutell C, Groitl P, Schreiner S. 2022. PML alternative splice products differentially regulate HAdV productive infection. Microbiology Spectrum. 2022.e0078522.doi:10.1123/spectrum.00785-22.
Stubbe M, Mai J, Paulus C, Stubbe HC, Berscheminski J, Karimi M, Hofmann S, Weber E, Hadian K, Hay RT, Groitl P, Dobner T, Nevels M., Schreiner S. 2020. HAdV E2A SUMOylation prevents antiviral response promoted by host PML-NB components. mBio. Mar 17;11(2):e00049-20.