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Cathomen

Prof. Dr.
Toni Cathomen

Center for Chronic Immunodeficiency
Institute for Transfusion Medicine and Gene Therapy
Director
Phone: 0049-761-270-34800

www.uniklinik-freiburg.de/itg-en

CV

  • 1998-2002 Postdoctoral Fellow, Laboratory of Genetics, The Salk Institute, La Jolla, USA
  • 2002-2003 Senior Research Associate, The Salk Institute, La Jolla, USA
  • 2003-2009 Assistant Professor of Molecular Virology, Charité Medical School, Berlin, Germany
  • 2009-2012 Associate Professor of Experimental Hematology, Hannover Medical School, Germany
  • Since 2012 Full Professor (W3) and Director of the Institute for Cell and Gene Therapy, Medical Center - University of Freiburg

Focus of research

  • To improve TALEN and CRISPR-Cas platforms for therapeutic applications in human stem cells
  • To develop disease models and cell therapies based on induced pluripotent stem cells (iPSCs)
  • To translate into the clinic cell and gene therapies for patients suffering from primary immunodeficiencies, HIV infection or leukemia

Selected publications

  • Lee SH, ... Cathomen T*, Kim J-S*. Failure to detect DNA-guided genome editing using Natronobacterium gregoryi argonaute (Correspondence). Nat Biotechnol. 2016; 35, 17-18 (*corresponding authors).
  • Müller M, ... Cathomen T*, Mussolino C*. Streptococcus thermophilus CRISPR-Cas9 systems enable specifi c editing of the human genome. Mol Ther. 2016; 24,636-44. (*corresponding authors).
  • Dreyer A-K, ... Cathomen T. TALEN-mediated functional correction of X-linked chronic granulomatous disease in patient-derived induced pluripotent stem cells. Biomaterials.2015; 69,191-200.
  • Rahman SH, ... Cathomen T. Rescue of DNA-PK signaling and T-cell differentiation by targeted genome editing in a prkdc deficient iPSC disease model. PLoS Genet. 2015; 11, e1005239.
  • Mussolino C, ... Cathomen T. TALENs facilitate targeted genome editing in human cells with high specifi city and low cytotoxicity. Nucleic Acids Res. 2014; 42,6762-73.