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Prof. Dr.
Ian Frew

Department of Medicine I
Centre for Translational Cell Research

BIOSS Centre for Biological Signalling
Phone: 0049-761-270-71831



  • 1994-1997 B.Sc (Hons. In Molecular Biology and Biochemistry), Australian National University, Canberra, Australia
  • 1998-2003 PhD, Peter MacCallum Cancer Center, University of Melbourne, Australia
  • 2003-2009 Postdoctoral scientist, Institute of Cell Biology, ETH Zurich, Switzerland
  • 2010-2016 Swiss National Science Foundation Assistant Professorship, Institute of Physiology, University of Zurich, Switzerland
  • Since 2017 Full Professor (W3) of Oncogenic Signalling, Medical Center - University of  Freiburg

Focus of research

  • Genetically engineered mouse tumour models
  • Identification of new cancer therapies though pre-clinical studies
  • Kidney tumours

Selected publications

  • Harlander S, Schönenberger D, Toussaint NC, Prummer M, Catalano A, Moch H, Wild PJ and Frew IJ. Combined Vhl, Trp53 and Rb1 mutation causes clear cell renal cell carcinoma in mice. Nature Medicine. 2017; 23: 869-877.
  • Schönenberger D, Harlander S, Rajski M, Jacobs RA, Lundby AK, Adlesic M, Hejhal T, Wild PJ, Lundby C and Frew IJ. Formation of renal cysts and tumours in Vhl/Trp53 defi cient mice requires HIF1alpha and HIF2alpha. Cancer Research. 2016; 76:2025-2036.
  • Albers J, Danzer C, Rechsteiner M, Lehmann H, Brandt L, Hejhal T, Catalano A, Busenhart P, Gonçalves AF, Brandt S, Bode PK, Bode-Lesniewska B, Wild PJ and Frew IJ. A versatile modular vector system for rapid combinatorial mammalian genetics. Journal of Clinical Investigation. 2015; 125:1603-19.
  • Lehmann H, Vicari D, Wild PJ and Frew IJ. Combined Vhl and Kif3a deletion accelerates renal cyst formation. Journal of the American Society of Nephrology. 2015; 26:2778-88.
  • Albers J, Rajski M, Schönenberger D, Harlander S, Schraml S, von Teichman A, Georgiev S, Wild PJ, Moch H, Krek W and Frew IJ. Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice. EMBO Molecular Medicine. 2013; 5:949-64.

Research methods

  • Mouse genetics
  • Lentiviruses