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Vogel

Prof. Dr.
Tanja Vogel

Institute of Anatomy and Cell Biology
Department of Molecular Embryology
Head of Department (temporary)
Phone: 0049-761-203-5086

www.anatomie2.uni-freiburg.de/en/staff/vogel-1

CV

  • 1988-1997 Studies of Biochemistry, University of Hannover and PhD examination 
  • 1997-2000 MRC Human Genetics Unit, Edinburgh, UK, Postdoctoral Fellow with Prof. H. Cooke
  • 2000-2005 MPI Biophysical Chemistry Göttingen, Postdoctoral Fellow with Prof. P. Gruss
  • 2005-2011 Neuroanatomy University of Göttingen, Habilitation Anatomy          
  • Since 2011 Professor (W2) of Anatomy, since 2016 Full Professor (W3), University of Freiburg
  • Since 2017 Speaker of the Research Training Group "MeInBio", University of Freiburg

Focus of research

  • Neurodevelopmental epigenetics: histone modifcations as determinants of neuronal differentiation
  • Neurodevelopmental disorders: Function of FOXG1 in controling non-coding RNAs in atypical Rett syndrome
  • Control of neurogenesis through extracellular TGFbeta signals

Selected publications

  • Roidl D, Hellbach N, Bovio P, Villarreal A, Heidrich S, Nestel S, Grüning B, Bönisch U, Vogel T. DOT1L activity promotes proliferation and protects cortical neural stem cells from activation of ATF4-DDIT3-mediated ER stress in vitro. Stem Cells. 2016; 34(1):233-45.
  • Backofen R, Vogel T. Biological and bioinformatical approaches to study crosstalk of longnon-coding RNAs and chromatin-modifying proteins. Cell Tissue Res. 2014; 356:507-26.
  • Büttner N, Johnsen SA, Kügler S, Vogel T. Af9/ Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of upper layers in the cerebral cortex. Proc Natl Acad Sci USA.2010; 107(15):7042-7.
  • Vogel T, Ahrens S, Buttner N, Krieglstein K. Transforming Growth Factor β Promotes Neuronal Cell Fate of Mouse Cortical and Hippocampal Progenitors In Vitro and In Vivo: Identification of Nedd9 as an Essential Signaling Component. Cereb Cortex. 2010; 20(3): 661-71.

Research methods

  • ChIP, RIP, NGS, Transcriptomics, SILAC Proteomics
  • CRISPR/Cas9, Lentivirus-mediated modification of gene expression
  • Differentiation of embryonic stem cells